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P30836

L-selectin (P30836)

Uniprot ID P30836
Protein Name L-selectin
Gene Name Sell
Species Rattus norvegicus (Rat)
Basic Information Experiments (6) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b)
Function Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. .
GO - Molecular function
  • calcium ion binding : ISS:UniProtKB
  • cell adhesion molecule binding : ISO:RGD
  • glycolipid binding : IDA:RGD
  • oligosaccharide binding : ISS:UniProtKB
  • protease binding : ISO:RGD
GO - Biological process
  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules : ISS:UniProtKB
  • leukocyte tethering or rolling : ISS:UniProtKB
  • positive regulation of neutrophil chemotaxis : IMP:RGD
  • regulation of apoptotic process : IDA:RGD
  • response to ATP : ISO:RGD
  • response to hyperoxia : IEP:RGD
  • response to linoleic acid : IEP:RGD
  • response to oleic acid : IEP:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.