| Signal peptide(a) |
Y |
Secretome P(b) |
0.847 |
| Function |
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. |
| GO - Molecular function |
- integrin binding : IPI:RGD
- metalloendopeptidase inhibitor activity : IMP:RGD
- protease binding : IBA:GO_Central
- zinc ion binding : ISS:UniProtKB
|
| GO - Biological process |
- aging : IEP:RGD
- central nervous system development : IEP:RGD
- negative regulation of cell proliferation : IDA:RGD
- negative regulation of membrane protein ectodomain proteolysis : IBA:GO_Central
- negative regulation of metallopeptidase activity : IEA:Ensembl
- negative regulation of mitotic cell cycle : IDA:RGD
- negative regulation of proteolysis : IMP:RGD
- negative regulation of Ras protein signal transduction : IDA:RGD
- positive regulation of adenylate cyclase activity : IMP:RGD
- positive regulation of MAPK cascade : IDA:RGD
- positive regulation of neuron differentiation : IDA:RGD
- regulation of Rap protein signal transduction : IDA:RGD
- response to cytokine : IEP:RGD
- response to drug : IEP:RGD
- response to hormone : IBA:GO_Central
- spermatogenesis : NAS:RGD
|