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P29533

Vascular cell adhesion protein 1 (P29533)

Uniprot ID P29533
Protein Name Vascular cell adhesion protein 1
Gene Name Vcam1
Species Mus musculus (Mouse)
Basic Information Experiments (3) Disease (12) Interactions
Signal peptide(a) Y Secretome P(b) 0.0
Function Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
GO - Molecular function
  • cell adhesion molecule binding : ISO:MGI
  • integrin binding : ISO:MGI
  • primary amine oxidase activity : ISO:MGI
GO - Biological process
  • amine metabolic process : ISO:MGI
  • calcium-mediated signaling using intracellular calcium source : ISO:MGI
  • cell adhesion : IDA:MGI
  • cell chemotaxis : ISO:MGI
  • cell-matrix adhesion : ISO:MGI
  • cellular response to glucose stimulus : IDA:MGI
  • chorio-allantoic fusion : IMP:MGI
  • embryonic placenta morphogenesis : IMP:MGI
  • heart development : IMP:MGI
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules : IMP:MGI
  • leukocyte cell-cell adhesion : IMP:MGI
  • leukocyte tethering or rolling : ISO:MGI
  • positive regulation of T cell proliferation : ISO:MGI
  • viral process : IEA:UniProtKB-KW
  • visceral serous pericardium development : TAS:DFLAT
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.