Interleukin-10 (P29456)

Uniprot ID P29456
Protein Name Interleukin-10
Gene Name Il10
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b)
Function Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity). .
GO - Molecular function
  • cytokine activity : ISO:RGD
  • interleukin-10 receptor binding : IDA:RGD
  • protein dimerization activity : ISO:RGD
GO - Biological process
  • aging : IEP:RGD
  • branching involved in labyrinthine layer morphogenesis : ISO:RGD
  • cellular response to estradiol stimulus : IEP:RGD
  • cellular response to hepatocyte growth factor stimulus : ISO:RGD
  • cellular response to lipopolysaccharide : ISO:RGD
  • defense response to bacterium : ISO:RGD
  • defense response to protozoan : ISO:RGD
  • immune response : IMP:RGD
  • inflammatory response : ISO:RGD
  • liver regeneration : IEP:RGD
  • negative regulation of apoptotic process : IMP:RGD
  • negative regulation of autophagy : ISO:RGD
  • negative regulation of B cell proliferation : ISS:UniProtKB
  • negative regulation of cell population proliferation : ISO:RGD
  • negative regulation of chronic inflammatory response to antigenic stimulus : ISO:RGD
  • negative regulation of cytokine activity : ISO:RGD
  • negative regulation of cytokine production : IMP:RGD
  • negative regulation of cytokine secretion involved in immune response : ISS:UniProtKB
  • negative regulation of endothelial cell apoptotic process : ISO:RGD
  • negative regulation of heterotypic cell-cell adhesion : ISO:RGD
  • negative regulation of hydrogen peroxide-induced neuron death : ISO:RGD
  • negative regulation of inflammatory response : IDA:RGD
  • negative regulation of interferon-gamma production : ISO:RGD
  • negative regulation of interleukin-12 production : ISO:RGD
  • negative regulation of interleukin-6 production : ISS:UniProtKB
  • negative regulation of membrane protein ectodomain proteolysis : ISS:UniProtKB
  • negative regulation of MHC class II biosynthetic process : ISO:RGD
  • negative regulation of myeloid dendritic cell activation : ISO:RGD
  • negative regulation of neuron apoptotic process : IDA:RGD
  • negative regulation of nitric oxide biosynthetic process : IDA:RGD
  • negative regulation of sensory perception of pain : IDA:RGD
  • negative regulation of tumor necrosis factor biosynthetic process : IDA:RGD
  • negative regulation of tumor necrosis factor production : ISO:RGD
  • negative regulation of vascular smooth muscle cell proliferation : ISO:RGD
  • positive regulation of B cell apoptotic process : ISS:UniProtKB
  • positive regulation of cell cycle : ISO:RGD
  • positive regulation of cytokine secretion : ISS:UniProtKB
  • positive regulation of DNA-binding transcription factor activity : ISS:UniProtKB
  • positive regulation of endothelial cell proliferation : ISO:RGD
  • positive regulation of macrophage activation : IDA:RGD
  • positive regulation of MHC class II biosynthetic process : ISO:RGD
  • positive regulation of pri-miRNA transcription by RNA polymerase II : ISO:RGD
  • positive regulation of receptor signaling pathway via JAK-STAT : ISO:RGD
  • positive regulation of sprouting angiogenesis : ISO:RGD
  • positive regulation of transcription by RNA polymerase II : ISO:RGD
  • positive regulation of transcription, DNA-templated : ISS:UniProtKB
  • receptor biosynthetic process : ISS:UniProtKB
  • regulation of gene expression : ISO:RGD
  • regulation of response to wounding : ISO:RGD
  • regulation of sensory perception of pain : IDA:RGD
  • regulation of synapse organization : IDA:RGD
  • response to activity : IEP:RGD
  • response to carbon monoxide : IEP:RGD
  • response to drug : IEP:RGD
  • response to glucocorticoid : IEP:RGD
  • response to inactivity : IEP:RGD
  • response to insulin : IEP:RGD
  • response to lipopolysaccharide : IEP:RGD
  • response to molecule of bacterial origin : ISS:UniProtKB
  • response to organic substance : IEP:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.