| Signal peptide(a) |
N |
Secretome P(b) |
0.335 |
| Function |
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. . |
| GO - Molecular function |
- cell adhesion molecule binding : IPI:UniProtKB
- natural killer cell lectin-like receptor binding : ISO:MGI
- phosphorylation-dependent protein binding : ISO:MGI
- phosphotyrosine residue binding : IPI:MGI
- protein kinase binding : ISO:MGI
- protein tyrosine phosphatase activity : IDA:MGI
- SH2 domain binding : IDA:MGI
- SH3 domain binding : IDA:MGI
- transmembrane receptor protein tyrosine phosphatase activity : ISS:UniProtKB
|
| GO - Biological process |
- abortive mitotic cell cycle : IMP:MGI
- B cell receptor signaling pathway : IMP:MGI
- cell differentiation : ISS:UniProtKB
- cell proliferation : ISS:UniProtKB
- cytokine-mediated signaling pathway : TAS:MGI
- hematopoietic progenitor cell differentiation : IMP:MGI
- intracellular signal transduction : IDA:MGI
- megakaryocyte development : IMP:MGI
- natural killer cell mediated cytotoxicity : IMP:MGI
- negative regulation of B cell receptor signaling pathway : IGI:MGI
- negative regulation of humoral immune response mediated by circulating immunoglobulin : IMP:MGI
- negative regulation of MAP kinase activity : IMP:MGI
- negative regulation of MAPK cascade : IMP:MGI
- negative regulation of peptidyl-tyrosine phosphorylation : IMP:MGI
- negative regulation of T cell proliferation : IMP:MGI
- negative regulation of T cell receptor signaling pathway : IMP:MGI
- peptidyl-tyrosine dephosphorylation : ISO:MGI
- peptidyl-tyrosine phosphorylation : ISO:MGI
- platelet aggregation : IMP:MGI
- platelet formation : IGI:MGI
- positive regulation of cell adhesion mediated by integrin : IMP:MGI
- positive regulation of cell proliferation : ISO:MGI
- positive regulation of phosphatidylinositol 3-kinase signaling : ISO:MGI
- protein dephosphorylation : IDA:MGI
- regulation of B cell differentiation : IMP:MGI
- regulation of ERK1 and ERK2 cascade : ISS:UniProtKB
- regulation of G1/S transition of mitotic cell cycle : ISO:MGI
- regulation of release of sequestered calcium ion into cytosol : IGI:MGI
|