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P28474

Alcohol dehydrogenase class-3 (P28474)

Uniprot ID P28474
Protein Name Alcohol dehydrogenase class-3
Gene Name Adh5
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.526
Function Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
GO - Molecular function
  • alcohol dehydrogenase (NAD) activity : IDA:MGI
  • fatty acid binding : ISO:MGI
  • formaldehyde dehydrogenase activity : ISO:MGI
  • protein homodimerization activity : IPI:MGI
  • S-(hydroxymethyl)glutathione dehydrogenase activity : IMP:MGI
  • zinc ion binding : ISO:MGI
GO - Biological process
  • ethanol catabolic process : ISO:MGI
  • ethanol oxidation : IEA:InterPro
  • formaldehyde catabolic process : IMP:MGI
  • peptidyl-cysteine S-nitrosylation : IMP:MGI
  • positive regulation of blood pressure : IMP:MGI
  • respiratory system process : IMP:MGI
  • response to lipopolysaccharide : IMP:MGI
  • response to nitrosative stress : IMP:MGI
  • response to redox state : ISO:MGI
  • retinoid metabolic process : IMP:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.