Metallothionein-3 (P28184)

Uniprot ID P28184
Protein Name Metallothionein-3
Gene Name Mt3
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.727
Function Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity). .
GO - Molecular function
  • cadmium ion binding : ISS:UniProtKB
  • copper ion binding : ISS:UniProtKB
  • cysteine-type endopeptidase inhibitor activity involved in apoptotic process : ISS:UniProtKB
  • drug binding : ISS:UniProtKB
  • metal ion binding : IDA:MGI
  • protein kinase activator activity : ISS:UniProtKB
  • zinc ion binding : IDA:UniProtKB
GO - Biological process
  • activation of protein kinase B activity : ISS:UniProtKB
  • astrocyte development : IDA:UniProtKB
  • brain development : IEA:Ensembl
  • cadmium ion homeostasis : IMP:UniProtKB
  • cellular lipid catabolic process : IMP:UniProtKB
  • cellular metal ion homeostasis : IDA:MGI
  • cellular response to cadmium ion : ISS:UniProtKB
  • cellular response to drug : ISS:UniProtKB
  • cellular response to hypoxia : IEA:Ensembl
  • cellular response to nitric oxide : ISS:UniProtKB
  • cellular response to oxidative stress : IDA:UniProtKB
  • cellular zinc ion homeostasis : IDA:UniProtKB
  • cholesterol catabolic process : IMP:UniProtKB
  • energy reserve metabolic process : IMP:UniProtKB
  • ERK1 and ERK2 cascade : ISS:UniProtKB
  • histone modification : ISS:UniProtKB
  • leptin-mediated signaling pathway : IMP:UniProtKB
  • negative regulation of apoptotic process : IMP:UniProtKB
  • negative regulation of autophagy : IMP:UniProtKB
  • negative regulation of axon extension : ISS:UniProtKB
  • negative regulation of cell growth : ISS:UniProtKB
  • negative regulation of cysteine-type endopeptidase activity : ISS:UniProtKB
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process : ISS:UniProtKB
  • negative regulation of hydrogen peroxide catabolic process : IEA:Ensembl
  • negative regulation of necrotic cell death : IMP:UniProtKB
  • negative regulation of neurogenesis : IDA:MGI
  • negative regulation of neuron apoptotic process : IDA:UniProtKB
  • negative regulation of oxidoreductase activity : ISS:UniProtKB
  • negative regulation of reactive oxygen species metabolic process : ISS:UniProtKB
  • negative regulation of transcription, DNA-templated : IMP:UniProtKB
  • positive regulation of catalytic activity : IMP:UniProtKB
  • positive regulation of cell death : IMP:UniProtKB
  • positive regulation of ERK1 and ERK2 cascade : IMP:UniProtKB
  • positive regulation of gene expression : IMP:UniProtKB
  • positive regulation of lysosomal membrane permeability : IMP:UniProtKB
  • positive regulation of necrotic cell death : ISS:UniProtKB
  • positive regulation of oxygen metabolic process : IMP:UniProtKB
  • positive regulation of protein phosphorylation : ISS:UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress : ISS:UniProtKB
  • positive regulation of transcription, DNA-templated : IMP:UniProtKB
  • positive regulation of vascular endothelial growth factor receptor signaling pathway : ISS:UniProtKB
  • protein import into nucleus, translocation : ISS:UniProtKB
  • protein kinase B signaling : ISS:UniProtKB
  • protein stabilization : ISS:UniProtKB
  • regulation of protein glycosylation : IMP:UniProtKB
  • regulation of response to food : IMP:UniProtKB
  • removal of superoxide radicals : ISS:UniProtKB
  • response to hypoxia : ISS:UniProtKB
  • response to oxidative stress : IMP:UniProtKB
  • zinc ion homeostasis : ISS:UniProtKB
  • zinc ion transport : IDA:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.