Signal peptide(a) |
N |
Secretome P(b) |
0.727 |
Function |
Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity). . |
GO - Molecular function |
- cadmium ion binding : ISS:UniProtKB
- copper ion binding : ISS:UniProtKB
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process : ISS:UniProtKB
- drug binding : ISS:UniProtKB
- metal ion binding : IDA:MGI
- protein kinase activator activity : ISS:UniProtKB
- zinc ion binding : IDA:UniProtKB
|
GO - Biological process |
- activation of protein kinase B activity : ISS:UniProtKB
- astrocyte development : IDA:UniProtKB
- brain development : IEA:Ensembl
- cadmium ion homeostasis : IMP:UniProtKB
- cellular lipid catabolic process : IMP:UniProtKB
- cellular metal ion homeostasis : IDA:MGI
- cellular response to cadmium ion : ISS:UniProtKB
- cellular response to drug : ISS:UniProtKB
- cellular response to hypoxia : IEA:Ensembl
- cellular response to nitric oxide : ISS:UniProtKB
- cellular response to oxidative stress : IDA:UniProtKB
- cellular zinc ion homeostasis : IDA:UniProtKB
- cholesterol catabolic process : IMP:UniProtKB
- energy reserve metabolic process : IMP:UniProtKB
- ERK1 and ERK2 cascade : ISS:UniProtKB
- histone modification : ISS:UniProtKB
- leptin-mediated signaling pathway : IMP:UniProtKB
- negative regulation of apoptotic process : IMP:UniProtKB
- negative regulation of autophagy : IMP:UniProtKB
- negative regulation of axon extension : ISS:UniProtKB
- negative regulation of cell growth : ISS:UniProtKB
- negative regulation of cysteine-type endopeptidase activity : ISS:UniProtKB
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process : ISS:UniProtKB
- negative regulation of hydrogen peroxide catabolic process : IEA:Ensembl
- negative regulation of necrotic cell death : IMP:UniProtKB
- negative regulation of neurogenesis : IDA:MGI
- negative regulation of neuron apoptotic process : IDA:UniProtKB
- negative regulation of oxidoreductase activity : ISS:UniProtKB
- negative regulation of reactive oxygen species metabolic process : ISS:UniProtKB
- negative regulation of transcription, DNA-templated : IMP:UniProtKB
- positive regulation of catalytic activity : IMP:UniProtKB
- positive regulation of cell death : IMP:UniProtKB
- positive regulation of ERK1 and ERK2 cascade : IMP:UniProtKB
- positive regulation of gene expression : IMP:UniProtKB
- positive regulation of lysosomal membrane permeability : IMP:UniProtKB
- positive regulation of necrotic cell death : ISS:UniProtKB
- positive regulation of oxygen metabolic process : IMP:UniProtKB
- positive regulation of protein phosphorylation : ISS:UniProtKB
- positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress : ISS:UniProtKB
- positive regulation of transcription, DNA-templated : IMP:UniProtKB
- positive regulation of vascular endothelial growth factor receptor signaling pathway : ISS:UniProtKB
- protein import into nucleus, translocation : ISS:UniProtKB
- protein kinase B signaling : ISS:UniProtKB
- protein stabilization : ISS:UniProtKB
- regulation of protein glycosylation : IMP:UniProtKB
- regulation of response to food : IMP:UniProtKB
- removal of superoxide radicals : ISS:UniProtKB
- response to hypoxia : ISS:UniProtKB
- response to oxidative stress : IMP:UniProtKB
- zinc ion homeostasis : ISS:UniProtKB
- zinc ion transport : IDA:UniProtKB
|