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P26638

Serine--tRNA ligase, cytoplasmic (P26638)

Uniprot ID P26638
Protein Name Serine--tRNA ligase, cytoplasmic
Gene Name Sars
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.371
Function Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA. .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • core promoter sequence-specific DNA binding : ISS:UniProtKB
  • protein homodimerization activity : ISO:MGI
  • serine-tRNA ligase activity : ISS:UniProtKB
GO - Biological process
  • negative regulation of angiogenesis : ISS:UniProtKB
  • negative regulation of transcription by RNA polymerase II : ISS:UniProtKB
  • negative regulation of vascular endothelial growth factor production : ISS:UniProtKB
  • selenocysteinyl-tRNA(Sec) biosynthetic process : IEA:UniProtKB-UniPathway
  • seryl-tRNA aminoacylation : ISS:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.