Radixin (P26043 )

Uniprot ID P26043
Protein Name Radixin
Gene Name Rdx
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b)
Function Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
GO - Molecular function
  • actin binding : ISO:MGI
  • ATPase binding : ISO:MGI
  • protein domain specific binding : IPI:UniProtKB
  • protein homodimerization activity : IMP:UniProtKB
GO - Biological process
  • apical protein localization : IMP:MGI
  • barbed-end actin filament capping : ISO:MGI
  • cellular response to platelet-derived growth factor stimulus : IEA:Ensembl
  • cellular response to thyroid hormone stimulus : IMP:UniProtKB
  • establishment of endothelial barrier : ISO:MGI
  • establishment of protein localization : IMP:UniProtKB
  • microvillus assembly : IMP:MGI
  • negative regulation of adherens junction organization : ISO:MGI
  • negative regulation of cell size : ISO:MGI
  • negative regulation of GTPase activity : ISO:MGI
  • negative regulation of homotypic cell-cell adhesion : ISO:MGI
  • positive regulation of cell migration : ISO:MGI
  • positive regulation of cellular protein catabolic process : ISO:MGI
  • positive regulation of early endosome to late endosome transport : ISO:MGI
  • positive regulation of G1/S transition of mitotic cell cycle : IMP:UniProtKB
  • positive regulation of gene expression : ISO:MGI
  • positive regulation of protein localization to early endosome : ISO:MGI
  • protein localization to plasma membrane : ISO:MGI
  • regulation of actin filament bundle assembly : ISO:MGI
  • regulation of cell shape : ISO:MGI
  • regulation of cell size : ISO:MGI
  • regulation of GTPase activity : ISO:MGI
  • regulation of organelle assembly : ISO:MGI
  • regulation of ruffle assembly : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.