Talin-1 (P26039)

Uniprot ID P26039
Protein Name Talin-1
Gene Name Tln1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.32
Function Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
GO - Molecular function
  • actin filament binding : IEA:InterPro
  • cadherin binding : ISO:MGI
  • integrin binding : IMP:CAFA
  • LIM domain binding : ISO:MGI
  • phosphatidylinositol binding : IMP:CAFA
  • phosphatidylserine binding : IMP:CAFA
  • protein-containing complex binding : ISO:MGI
  • structural constituent of cytoskeleton : IEA:InterPro
  • vinculin binding : ISO:MGI
GO - Biological process
  • cell adhesion : IEA:InterPro
  • cell-substrate junction assembly : IMP:MGI
  • cortical actin cytoskeleton organization : IMP:MGI
  • cytoskeletal anchoring at plasma membrane : IEA:InterPro
  • integrin activation : IMP:CAFA
  • integrin-mediated signaling pathway : IMP:CAFA
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.