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P25801

Rhombotin-2 (P25801)

Uniprot ID P25801
Protein Name Rhombotin-2
Gene Name Lmo2
Species Mus musculus (Mouse)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. .
GO - Molecular function
  • bHLH transcription factor binding : ISO:MGI
  • chromatin binding : IDA:MGI
  • cofactor binding : ISO:MGI
  • DNA-binding transcription activator activity, RNA polymerase II-specific : ISO:MGI
  • DNA-binding transcription factor activity, RNA polymerase II-specific : ISO:MGI
  • E-box binding : ISO:MGI
  • metal ion binding : IEA:UniProtKB-KW
  • RNA polymerase II activating transcription factor binding : ISO:MGI
  • RNA polymerase II regulatory region sequence-specific DNA binding : ISO:MGI
GO - Biological process
  • cellular response to thyroid hormone stimulus : ISO:MGI
  • embryonic hemopoiesis : IGI:MGI
  • mRNA transcription by RNA polymerase II : ISO:MGI
  • negative regulation of erythrocyte differentiation : IMP:UniProtKB
  • positive regulation of transcription by RNA polymerase II : IGI:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.