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P25785

Metalloproteinase inhibitor 2 (P25785)

Uniprot ID P25785
Protein Name Metalloproteinase inhibitor 2
Gene Name Timp2
Species Mus musculus (Mouse)
Basic Information Experiments (6) Disease (10) Interactions
Signal peptide(a) Y Secretome P(b) 0.0
Function Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
GO - Molecular function
  • enzyme activator activity : IMP:MGI
  • integrin binding : IDA:MGI
  • metalloendopeptidase inhibitor activity : IMP:MGI
  • protease binding : ISO:MGI
  • zinc ion binding : ISS:UniProtKB
GO - Biological process
  • cellular response to organic substance : IDA:MGI
  • negative regulation of cell proliferation : IDA:MGI
  • negative regulation of membrane protein ectodomain proteolysis : IBA:GO_Central
  • negative regulation of metallopeptidase activity : ISO:MGI
  • negative regulation of mitotic cell cycle : ISO:MGI
  • negative regulation of proteolysis : ISO:MGI
  • negative regulation of Ras protein signal transduction : ISO:MGI
  • positive regulation of adenylate cyclase activity : ISO:MGI
  • positive regulation of MAPK cascade : ISO:MGI
  • positive regulation of neuron differentiation : ISO:MGI
  • regulation of cAMP metabolic process : IDA:MGI
  • regulation of MAPK cascade : IDA:MGI
  • regulation of neuron differentiation : IDA:MGI
  • regulation of Rap protein signal transduction : ISO:MGI
  • response to cytokine : IBA:GO_Central
  • response to hormone : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.