Beta-nerve growth factor (P25427)

Uniprot ID	P25427
Protein Name	Beta-nerve growth factor
Gene Name	Ngf
Species	Rattus norvegicus (Rat)

Signal peptide^(a)	Y	Secretome P^(b)	0.855
Function	Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity). .
GO - Molecular function	cysteine-type endopeptidase activator activity involved in apoptotic process : ISO:RGD death receptor agonist activity : ISO:RGD growth factor activity : IBA:GO_Central lipid binding : IEA:UniProtKB-KW metalloendopeptidase inhibitor activity : ISS:UniProtKB nerve growth factor receptor binding : ISO:RGD transmembrane receptor protein tyrosine kinase activator activity : ISO:RGD
GO - Biological process	activation of cysteine-type endopeptidase activity involved in apoptotic process : ISO:RGD adult locomotory behavior : IMP:RGD aging : IEP:RGD circadian rhythm : ISO:RGD extrinsic apoptotic signaling pathway in absence of ligand : ISO:RGD extrinsic apoptotic signaling pathway via death domain receptors : ISO:RGD inflammatory response : IEP:RGD memory : IMP:RGD modulation of chemical synaptic transmission : IBA:GO_Central negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway : NAS:ParkinsonsUK-UCL negative regulation of neuron apoptotic process : IMP:UniProtKB negative regulation of type B pancreatic cell apoptotic process : IMP:RGD nerve development : IBA:GO_Central nerve growth factor signaling pathway : ISO:RGD neuron apoptotic process : ISO:RGD neuron development : ISO:RGD neuron projection development : IDA:RGD neuron projection morphogenesis : ISO:RGD peripheral nervous system development : ISO:RGD positive regulation of axon extension : ISO:RGD positive regulation of cell growth : IDA:RGD positive regulation of cell population proliferation : IDA:RGD positive regulation of collateral sprouting : ISO:RGD positive regulation of DNA binding : ISO:RGD positive regulation of DNA-binding transcription factor activity : IDA:MGI positive regulation of ERK1 and ERK2 cascade : IDA:RGD positive regulation of gene expression : ISO:RGD positive regulation of neuron differentiation : IDA:RGD positive regulation of neuron maturation : ISO:RGD positive regulation of neuron projection development : ISO:RGD positive regulation of neurotrophin TRK receptor signaling pathway : IDA:MGI positive regulation of protein autophosphorylation : IDA:MGI positive regulation of protein binding : IMP:UniProtKB positive regulation of protein phosphorylation : IDA:UniProtKB positive regulation of protein ubiquitination : ISO:RGD positive regulation of Ras protein signal transduction : ISO:RGD positive regulation of stem cell proliferation : IDA:RGD regulation of neuron differentiation : ISO:RGD regulation of neurotransmitter secretion : ISO:RGD regulation of release of sequestered calcium ion into cytosol : ISO:RGD response to drug : IEP:RGD response to electrical stimulus : IEP:RGD response to glucocorticoid : IEP:RGD response to lipopolysaccharide : IEP:RGD response to mechanical stimulus : IEP:RGD response to nicotine : IEP:RGD response to organic cyclic compound : IEP:RGD response to organic substance : IEP:RGD response to ozone : IEP:RGD response to peptide hormone : IEP:RGD response to radiation : IEP:RGD sensory perception of pain : IMP:RGD transmembrane receptor protein tyrosine kinase signaling pathway : IBA:GO_Central

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}