| Signal peptide(a) |
Y |
Secretome P(b) |
|
| Function |
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity (By similarity). . |
| GO - Molecular function |
- cytokine activity : IEA:InterPro
- interleukin-1 receptor antagonist activity : ISO:RGD
- interleukin-1 receptor binding : IDA:RGD
- interleukin-1 type I receptor antagonist activity : ISO:RGD
- interleukin-1 type II receptor antagonist activity : ISO:RGD
- interleukin-1, type I receptor binding : ISO:RGD
- interleukin-1, type II receptor binding : ISO:RGD
|
| GO - Biological process |
- acute-phase response : ISO:RGD
- carboxylic acid metabolic process : IEP:RGD
- cellular response to norepinephrine stimulus : IEP:RGD
- chronic inflammatory response to antigenic stimulus : IEP:RGD
- female pregnancy : IEP:RGD
- fever generation : IMP:RGD
- inflammatory response : IBA:GO_Central
- inflammatory response to antigenic stimulus : IBA:GO_Central
- insulin secretion : ISO:RGD
- lipid metabolic process : ISO:RGD
- memory : IMP:RGD
- negative regulation of apoptotic process : IMP:RGD
- negative regulation of cell migration : IDA:RGD
- negative regulation of glutamate secretion : IMP:RGD
- negative regulation of heterotypic cell-cell adhesion : ISO:RGD
- negative regulation of interleukin-1-mediated signaling pathway : ISO:RGD
- negative regulation of membrane potential : IDA:RGD
- negative regulation of signal transduction : TAS:RGD
- positive regulation of JUN kinase activity : IMP:RGD
- response to activity : IEP:RGD
- response to drug : IEP:RGD
- response to glucocorticoid : ISO:RGD
- response to interleukin-1 : IEP:RGD
- response to interleukin-4 : IEP:RGD
- response to lipopolysaccharide : IEP:RGD
- response to organic cyclic compound : IEP:RGD
- response to organonitrogen compound : IEP:RGD
- response to starvation : IEP:RGD
- sensory perception of pain : IMP:RGD
|