| Signal peptide(a) |
Y |
Secretome P(b) |
0.92 |
| Function |
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. |
| GO - Molecular function |
- cytokine activity : IBA:GO_Central
- interleukin-1 receptor antagonist activity : ISO:MGI
- interleukin-1 receptor binding : ISO:MGI
- interleukin-1 Type I receptor antagonist activity : ISO:MGI
- interleukin-1 Type II receptor antagonist activity : ISO:MGI
- interleukin-1, Type I receptor binding : ISO:MGI
- interleukin-1, Type II receptor binding : ISO:MGI
|
| GO - Biological process |
- acute-phase response : ISO:MGI
- cytokine-mediated signaling pathway : IBA:GO_Central
- fever generation : ISO:MGI
- immune response : IEA:InterPro
- insulin secretion : IMP:MGI
- lipid metabolic process : IMP:MGI
- memory : ISO:MGI
- negative regulation of apoptotic process : ISO:MGI
- negative regulation of cell migration : ISO:MGI
- negative regulation of glutamate secretion : ISO:MGI
- negative regulation of heterotypic cell-cell adhesion : ISO:MGI
- negative regulation of interleukin-1-mediated signaling pathway : ISO:MGI
- negative regulation of membrane potential : ISO:MGI
- positive regulation of JUN kinase activity : ISO:MGI
- response to glucocorticoid : ISO:MGI
- sensory perception of pain : ISO:MGI
|