Leukotriene A-4 hydrolase (P24527)

Uniprot ID P24527
Protein Name Leukotriene A-4 hydrolase
Gene Name Lta4h
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.596
Function Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. .
GO - Molecular function
  • aminopeptidase activity : ISS:UniProtKB
  • epoxide hydrolase activity : ISS:UniProtKB
  • leukotriene-A4 hydrolase activity : ISS:UniProtKB
  • metalloaminopeptidase activity : ISO:MGI
  • peptide binding : IBA:GO_Central
  • zinc ion binding : ISS:UniProtKB
GO - Biological process
  • cellular lipid metabolic process : IBA:GO_Central
  • cellular protein metabolic process : ISO:MGI
  • leukotriene biosynthetic process : ISS:UniProtKB
  • leukotriene metabolic process : ISO:MGI
  • peptide catabolic process : ISS:UniProtKB
  • proteolysis : IBA:GO_Central
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.