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P24452

Macrophage-capping protein (P24452)

Uniprot ID P24452
Protein Name Macrophage-capping protein
Gene Name Capg
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.0
Function Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. Uncapping occurs either when Ca(2+) falls or when the concentration of polyphosphoinositide rises, both at low and high Ca(2+).
GO - Molecular function
  • actin filament binding : IEA:InterPro
  • cadherin binding : ISO:MGI
  • protein domain specific binding : ISO:MGI
  • protein-containing complex binding : ISO:MGI
GO - Biological process
  • barbed-end actin filament capping : IEA:InterPro
  • cell projection assembly : IDA:MGI
  • cellular response to interferon-gamma : IDA:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.