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P24368

Peptidyl-prolyl cis-trans isomerase B (P24368)

Uniprot ID P24368
Protein Name Peptidyl-prolyl cis-trans isomerase B
Gene Name Ppib
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (1) Interactions
Signal peptide(a) Y Secretome P(b)
Function PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. .
GO - Molecular function
  • cyclosporin A binding : ISS:UniProtKB
  • peptidyl-prolyl cis-trans isomerase activity : ISS:UniProtKB
  • RNA polymerase binding : ISO:RGD
  • unfolded protein binding : IBA:GO_Central
GO - Biological process
  • bone development : ISO:RGD
  • chaperone-mediated protein folding : ISS:UniProtKB
  • nuclear transport : TAS:RGD
  • positive regulation by host of viral genome replication : ISO:RGD
  • positive regulation by host of viral process : ISO:RGD
  • positive regulation of multicellular organism growth : ISO:RGD
  • protein peptidyl-prolyl isomerization : ISS:UniProtKB
  • protein refolding : IBA:GO_Central
  • protein stabilization : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.