Cathepsin D (P24268)

Uniprot ID P24268
Protein Name Cathepsin D
Gene Name Ctsd
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b)
Function Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. .
GO - Molecular function
  • aspartic-type endopeptidase activity : ISO:RGD
  • aspartic-type peptidase activity : ISO:RGD
  • endopeptidase activity : IDA:RGD
  • hydrolase activity : ISO:RGD
  • peptidase activity : ISO:RGD
  • peptide binding : IDA:RGD
GO - Biological process
  • autophagosome assembly : ISO:RGD
  • lipoprotein catabolic process : ISO:RGD
  • positive regulation of apoptotic process : ISO:RGD
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process : ISO:RGD
  • protein catabolic process : IBA:GO_Central
  • proteolysis : IDA:RGD
  • regulation of establishment of protein localization : ISO:RGD
  • response to nutrient levels : IEP:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.