| Signal peptide(a) |
Y |
Secretome P(b) |
0.0 |
| Function |
Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. . |
| GO - Molecular function |
- endopeptidase activity : ISO:RGD
- metal ion binding : IEA:UniProtKB-KW
- nerve growth factor binding : ISO:RGD
- peptidase activity : ISO:RGD
- peptide binding : ISO:RGD
- protease binding : ISO:RGD
- serine-type endopeptidase activity : IMP:RGD
- serine-type endopeptidase inhibitor activity : ISO:RGD
|
| GO - Biological process |
- aging : IEP:RGD
- dibasic protein processing : ISO:RGD
- negative regulation of low-density lipoprotein particle receptor catabolic process : ISO:RGD
- negative regulation of transforming growth factor beta1 production : ISO:RGD
- nerve growth factor production : ISO:RGD
- peptide biosynthetic process : ISO:RGD
- peptide hormone processing : ISO:RGD
- positive regulation of cell migration : IMP:RGD
- positive regulation of transforming growth factor beta receptor signaling pathway : IMP:RGD
- positive regulation of transforming growth factor beta1 activation : ISS:UniProtKB
- protein processing : IDA:RGD
- regulation of endopeptidase activity : ISO:RGD
- regulation of low-density lipoprotein particle receptor biosynthetic process : ISO:RGD
- regulation of protein catabolic process : ISO:RGD
- regulation of signal transduction : ISO:RGD
- secretion by cell : ISO:RGD
- signal peptide processing : ISO:RGD
- viral life cycle : ISO:RGD
- zymogen activation : ISO:RGD
- zymogen inhibition : ISO:RGD
|