Plasminogen activator inhibitor 1 (P22777)

Uniprot ID	P22777
Protein Name	Plasminogen activator inhibitor 1
Gene Name	Serpine1
Species	Mus musculus (Mouse)

Signal peptide^(a)	Y	Secretome P^(b)	0.0
Function	Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (By similarity). Involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (PubMed:28722352). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity). .
GO - Molecular function	protease binding : ISO:MGI serine-type endopeptidase inhibitor activity : IDA:MGI signaling receptor binding : ISO:MGI
GO - Biological process	cellular response to drug : ISO:MGI cellular response to interleukin-1 : ISO:MGI cellular response to lipopolysaccharide : ISO:MGI cellular response to transforming growth factor beta stimulus : IDA:MGI defense response to Gram-negative bacterium : IMP:BHF-UCL dentinogenesis : ISO:MGI female gonad development : ISO:MGI negative regulation of cell adhesion mediated by integrin : ISO:MGI negative regulation of cell migration : ISO:MGI negative regulation of endopeptidase activity : ISO:MGI negative regulation of endothelial cell apoptotic process : ISO:MGI negative regulation of extrinsic apoptotic signaling pathway via death domain receptors : ISO:MGI negative regulation of fibrinolysis : ISO:MGI negative regulation of gene expression : ISO:MGI negative regulation of plasminogen activation : IMP:BHF-UCL negative regulation of smooth muscle cell migration : ISO:MGI negative regulation of smooth muscle cell-matrix adhesion : ISO:MGI negative regulation of vascular wound healing : IMP:BHF-UCL placenta development : IMP:MGI positive regulation of angiogenesis : IMP:BHF-UCL positive regulation of blood coagulation : ISO:MGI positive regulation of calcium ion import : ISO:MGI positive regulation of coagulation : ISO:MGI positive regulation of collagen biosynthetic process : ISO:MGI positive regulation of fibroblast proliferation : ISO:MGI positive regulation of gene expression : ISO:MGI positive regulation of inflammatory response : ISO:MGI positive regulation of interleukin-8 production : ISO:MGI positive regulation of keratinocyte migration : ISO:MGI positive regulation of leukotriene production involved in inflammatory response : ISO:MGI positive regulation of monocyte chemotaxis : ISO:MGI positive regulation of odontoblast differentiation : ISO:MGI positive regulation of receptor-mediated endocytosis : ISO:MGI regulation of angiogenesis : IDA:MGI regulation of cell proliferation : IGI:MGI regulation of signaling receptor activity : ISO:MGI replicative senescence : ISO:MGI wound healing : ISO:MGI

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}