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P21956

Lactadherin (P21956)

Uniprot ID P21956
Protein Name Lactadherin
Gene Name Mfge8
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (3) Interactions
Signal peptide(a) Y Secretome P(b) 0.751
Function Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction (By similarity). Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization. .
GO - Molecular function
  • integrin binding : IDA:BHF-UCL
  • phosphatidylethanolamine binding : IDA:MGI
  • phosphatidylserine binding : IDA:MGI
GO - Biological process
  • angiogenesis : IEA:UniProtKB-KW
  • apoptotic cell clearance : IDA:BHF-UCL
  • cell adhesion : IEA:UniProtKB-KW
  • phagocytosis, engulfment : IDA:MGI
  • phagocytosis, recognition : IDA:MGI
  • positive regulation of phagocytosis : IDA:MGI
  • single fertilization : IEA:UniProtKB-KW
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.