Follistatin (P21674)

Uniprot ID P21674
Protein Name Follistatin
Gene Name Fst
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b) 0.571
Function Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
GO - Molecular function
  • activin binding : ISO:RGD
  • activin receptor antagonist activity : ISO:RGD
  • heparan sulfate proteoglycan binding : IDA:RGD
GO - Biological process
  • BMP signaling pathway : ISO:RGD
  • cell differentiation : IBA:GO_Central
  • female gonad development : ISO:RGD
  • gamete generation : ISO:RGD
  • hair follicle morphogenesis : ISO:RGD
  • hematopoietic progenitor cell differentiation : ISO:RGD
  • keratinocyte proliferation : ISO:RGD
  • multicellular organism development : IBA:GO_Central
  • negative regulation of activin receptor signaling pathway : ISO:RGD
  • negative regulation of cell differentiation : ISO:RGD
  • negative regulation of follicle-stimulating hormone secretion : TAS:RGD
  • negative regulation of transcription by RNA polymerase II : ISO:RGD
  • odontogenesis of dentin-containing tooth : ISO:RGD
  • pattern specification process : ISO:RGD
  • positive regulation of hair follicle development : ISO:RGD
  • regulation of BMP signaling pathway : IBA:GO_Central
  • skeletal system development : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.