| Signal peptide(a) |
N |
Secretome P(b) |
0.565 |
| Function |
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM-and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). . |
| GO - Molecular function |
- actin filament binding : IDA:BHF-UCL
- cadherin binding : HDA:BHF-UCL
- Fc-gamma receptor I complex binding : IDA:BHF-UCL
- G protein-coupled receptor binding : IPI:UniProtKB
- GTPase binding : IPI:UniProtKB
- ion channel binding : IPI:BHF-UCL
- kinase binding : IPI:UniProtKB
- mu-type opioid receptor binding : IEA:Ensembl
- potassium channel regulator activity : IDA:BHF-UCL
- protein homodimerization activity : IDA:BHF-UCL
- Rac GTPase binding : IDA:BHF-UCL
- Ral GTPase binding : IDA:BHF-UCL
- Rho GTPase binding : IDA:BHF-UCL
- RNA binding : HDA:UniProtKB
- SMAD binding : IEA:Ensembl
- small GTPase binding : IDA:BHF-UCL
- transcription factor binding : IPI:UniProtKB
|
| GO - Biological process |
- actin crosslink formation : IDA:BHF-UCL
- actin cytoskeleton reorganization : IDA:BHF-UCL
- adenylate cyclase-inhibiting dopamine receptor signaling pathway : IMP:BHF-UCL
- cell junction assembly : TAS:Reactome
- cerebral cortex development : IEA:Ensembl
- cilium assembly : IMP:UniProtKB
- cytoplasmic sequestering of protein : IMP:BHF-UCL
- defense response to virus : TAS:Reactome
- establishment of protein localization : IDA:BHF-UCL
- establishment of Sertoli cell barrier : IEA:Ensembl
- formation of radial glial scaffolds : IEA:Ensembl
- mitotic spindle assembly : IDA:MGI
- mRNA transcription by RNA polymerase II : IEA:Ensembl
- negative regulation of apoptotic process : IMP:CACAO
- negative regulation of DNA-binding transcription factor activity : IDA:UniProtKB
- negative regulation of protein catabolic process : IMP:BHF-UCL
- negative regulation of transcription by RNA polymerase I : IDA:CACAO
- platelet activation : TAS:Reactome
- platelet aggregation : HMP:UniProtKB
- platelet degranulation : TAS:Reactome
- positive regulation of actin filament bundle assembly : IEA:Ensembl
- positive regulation of I-kappaB kinase/NF-kappaB signaling : HMP:UniProtKB
- positive regulation of integrin-mediated signaling pathway : IMP:CACAO
- positive regulation of neural precursor cell proliferation : IEA:Ensembl
- positive regulation of neuron migration : IEA:Ensembl
- positive regulation of potassium ion transmembrane transport : IDA:BHF-UCL
- positive regulation of protein import into nucleus : IMP:UniProtKB
- positive regulation of substrate adhesion-dependent cell spreading : IMP:CACAO
- protein localization to bicellular tight junction : IEA:Ensembl
- protein localization to cell surface : IDA:BHF-UCL
- protein localization to plasma membrane : IDA:BHF-UCL
- protein stabilization : IMP:BHF-UCL
- receptor clustering : IDA:BHF-UCL
- regulation of cell migration : IDA:UniProtKB
- regulation of membrane repolarization during atrial cardiac muscle cell action potential : IC:BHF-UCL
- regulation of membrane repolarization during cardiac muscle cell action potential : ISS:BHF-UCL
- semaphorin-plexin signaling pathway : IGI:WormBase
- tubulin deacetylation : IMP:CACAO
- wound healing, spreading of cells : IDA:UniProtKB
|