Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
P21263

Nestin (P21263)

Uniprot ID P21263
Protein Name Nestin
Gene Name Nes
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Required for brain and eye development (By similarity). Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. .
GO - Molecular function
  • CCR5 chemokine receptor binding : IPI:RGD
  • intermediate filament binding : ISS:UniProtKB
GO - Biological process
  • brain development : ISS:UniProtKB
  • cell projection morphogenesis : ISO:RGD
  • embryonic camera-type eye development : ISS:UniProtKB
  • G2/M transition of mitotic cell cycle : ISO:RGD
  • negative regulation of catalytic activity : ISO:RGD
  • negative regulation of neuron apoptotic process : ISO:RGD
  • negative regulation of protein binding : ISO:RGD
  • nervous system development : ISO:RGD
  • neuron differentiation : NAS:RGD
  • positive regulation of intermediate filament depolymerization : IDA:UniProtKB
  • positive regulation of neural precursor cell proliferation : IMP:UniProtKB
  • response to drug : IEP:RGD
  • response to ionizing radiation : IEP:RGD
  • response to nutrient levels : IEP:RGD
  • stem cell proliferation : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.