Brain-derived neurotrophic factor (P21237)

Uniprot ID P21237
Protein Name Brain-derived neurotrophic factor
Gene Name Bdnf
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.89
Function Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:27457814). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (PubMed:8139657, PubMed:15486301, PubMed:17023662, PubMed:27457814, PubMed:29909994). .[BDNF precursor form]: Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:27457814). Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD) (PubMed:27457814). Binding to NGFR and SORCS2 promotes neuronal apoptosis (PubMed:24908487). Promotes neuronal growth cone collapse (PubMed:24908487, PubMed:27457814). {ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:27457814, ECO:0000269|PubMed:29909994}.
GO - Molecular function
  • growth factor activity : IBA:GO_Central
  • neurotrophin TRKB receptor binding : ISO:MGI
GO - Biological process
  • axon extension : IDA:MGI
  • axon guidance : IMP:MGI
  • axon target recognition : IMP:MGI
  • behavioral fear response : IMP:MGI
  • circadian rhythm : IEP:UniProtKB
  • collateral sprouting : ISO:MGI
  • dendrite development : IMP:MGI
  • dendrite extension : IDA:MGI
  • excitatory postsynaptic potential : ISO:MGI
  • fear response : IMP:MGI
  • feeding behavior : IMP:MGI
  • gamma-aminobutyric acid signaling pathway : IDA:MGI
  • glutamate secretion : IPI:MGI
  • inhibitory postsynaptic potential : IMP:MGI
  • inner ear development : IMP:MGI
  • learning : ISO:MGI
  • learning or memory : IMP:MGI
  • mechanoreceptor differentiation : IGI:MGI
  • memory : IBA:GO_Central
  • mitochondrial electron transport, NADH to ubiquinone : ISO:MGI
  • modulation of chemical synaptic transmission : IBA:GO_Central
  • negative regulation of apoptotic process : IDA:MGI
  • negative regulation of apoptotic signaling pathway : IGI:ARUK-UCL
  • negative regulation of cell death : IMP:MGI
  • negative regulation of myotube differentiation : ISO:MGI
  • negative regulation of neuroblast proliferation : IDA:MGI
  • negative regulation of neuron apoptotic process : IMP:MGI
  • negative regulation of neuron death : ISO:MGI
  • negative regulation of striated muscle tissue development : ISO:MGI
  • negative regulation of synaptic transmission, GABAergic : IDA:MGI
  • nerve development : IMP:MGI
  • nerve growth factor signaling pathway : IBA:GO_Central
  • nervous system development : ISO:MGI
  • neuron projection extension : ISO:MGI
  • neuron projection morphogenesis : IBA:GO_Central
  • neuron recognition : IMP:MGI
  • peripheral nervous system development : IBA:GO_Central
  • positive regulation of collateral sprouting : IDA:MGI
  • positive regulation of DNA-binding transcription factor activity : ISO:MGI
  • positive regulation of glucocorticoid receptor signaling pathway : ISO:MGI
  • positive regulation of long-term neuronal synaptic plasticity : ISO:MGI
  • positive regulation of neuron differentiation : IDA:MGI
  • positive regulation of neuron projection development : IGI:ARUK-UCL
  • positive regulation of peptidyl-serine phosphorylation : IDA:MGI
  • positive regulation of receptor binding : ISO:MGI
  • positive regulation of synapse assembly : ISO:MGI
  • regeneration : ISO:MGI
  • regulation of axon extension : ISO:MGI
  • regulation of collateral sprouting : IGI:MGI
  • regulation of long-term neuronal synaptic plasticity : ISO:MGI
  • regulation of metabolic process : IMP:MGI
  • regulation of neuron apoptotic process : IDA:MGI
  • regulation of neuron differentiation : IBA:GO_Central
  • regulation of retinal cell programmed cell death : IDA:MGI
  • regulation of short-term neuronal synaptic plasticity : ISO:MGI
  • regulation of synaptic plasticity : IDA:MGI
  • response to drug : IMP:MGI
  • retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission : IMP:SynGO
  • synapse assembly : ISO:MGI
  • taste bud development : IMP:MGI
  • transmembrane receptor protein tyrosine kinase signaling pathway : IBA:GO_Central
  • ureteric bud development : IDA:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.