Complement C2 (P21180)

Uniprot ID P21180
Protein Name Complement C2
Gene Name C2
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.608
Function Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
GO - Molecular function
  • metal ion binding : IEA:UniProtKB-KW
  • serine-type endopeptidase activity : IEA:InterPro
GO - Biological process
  • complement activation : ISO:MGI
  • complement activation, classical pathway : IEA:UniProtKB-KW
  • innate immune response : IEA:UniProtKB-KW
  • positive regulation of apoptotic cell clearance : ISO:MGI
  • response to nutrient : IEA:Ensembl
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.