Plasminogen activator inhibitor 1 (P20961)

Uniprot ID	P20961
Protein Name	Plasminogen activator inhibitor 1
Gene Name	Serpine1
Species	Rattus norvegicus (Rat)

Signal peptide^(a)	Y	Secretome P^(b)
Function	Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence (By similarity). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity). .
GO - Molecular function	protease binding : IDA:RGD serine-type endopeptidase inhibitor activity : IDA:RGD signaling receptor binding : ISO:RGD
GO - Biological process	angiogenesis : ISO:RGD cellular response to aldosterone : IEP:RGD cellular response to angiotensin : IEP:RGD cellular response to ATP : IEP:RGD cellular response to cAMP : IEP:RGD cellular response to cGMP : IEP:RGD cellular response to cycloheximide : IEP:RGD cellular response to dexamethasone stimulus : IEP:RGD cellular response to drug : IDA:RGD cellular response to fibroblast growth factor stimulus : IEP:RGD cellular response to follicle-stimulating hormone stimulus : IEP:RGD cellular response to glucagon stimulus : IEP:RGD cellular response to glucose stimulus : IEP:RGD cellular response to gravity : IEP:RGD cellular response to growth factor stimulus : IEP:RGD cellular response to hydrogen peroxide : IEP:RGD cellular response to hypoxia : IEP:RGD cellular response to insulin stimulus : IEP:RGD cellular response to interleukin-1 : IDA:RGD cellular response to leukemia inhibitory factor : IEP:RGD cellular response to lipopolysaccharide : IEP:RGD cellular response to low-density lipoprotein particle stimulus : IEP:RGD cellular response to mechanical stimulus : IEP:RGD cellular response to metal ion : IEP:RGD cellular response to nerve growth factor stimulus : IEP:RGD cellular response to nicotine : IEP:RGD cellular response to organic cyclic compound : IEP:RGD cellular response to platelet-derived growth factor stimulus : IEP:RGD cellular response to potassium ion : IEP:RGD cellular response to resveratrol : IEP:RGD cellular response to transforming growth factor beta stimulus : IEP:RGD chronological cell aging : ISO:RGD decidualization : IEP:RGD defense response to Gram-negative bacterium : ISO:RGD dentinogenesis : ISO:RGD female gonad development : IDA:RGD glucose homeostasis : IEP:RGD mast cell activation : IEP:RGD negative regulation of cell adhesion mediated by integrin : ISO:RGD negative regulation of cell migration : IDA:RGD negative regulation of endopeptidase activity : IDA:RGD negative regulation of endothelial cell apoptotic process : ISO:RGD negative regulation of extrinsic apoptotic signaling pathway via death domain receptors : ISO:RGD negative regulation of fibrinolysis : ISO:RGD negative regulation of gene expression : IMP:RGD negative regulation of plasminogen activation : ISO:RGD negative regulation of smooth muscle cell migration : ISO:RGD negative regulation of smooth muscle cell-matrix adhesion : ISO:RGD negative regulation of vascular wound healing : ISO:RGD placenta development : ISO:RGD positive regulation of angiogenesis : ISO:RGD positive regulation of blood coagulation : ISO:RGD positive regulation of calcium ion import : IMP:RGD positive regulation of coagulation : IMP:RGD positive regulation of collagen biosynthetic process : IMP:RGD positive regulation of epithelium regeneration : IMP:RGD positive regulation of fibroblast proliferation : IMP:RGD positive regulation of gene expression : IMP:RGD positive regulation of inflammatory response : ISO:RGD positive regulation of interleukin-8 production : ISO:RGD positive regulation of keratinocyte migration : IMP:RGD positive regulation of leukotriene production involved in inflammatory response : ISO:RGD positive regulation of monocyte chemotaxis : ISO:RGD positive regulation of odontoblast differentiation : ISO:RGD positive regulation of receptor-mediated endocytosis : IMP:BHF-UCL regulation of angiogenesis : ISO:RGD regulation of cell population proliferation : ISO:RGD regulation of signaling receptor activity : ISO:RGD replicative senescence : ISS:UniProtKB response to cytokine : IEP:RGD response to epidermal growth factor : IEP:RGD response to estrogen : IEP:RGD response to hyperoxia : IEP:RGD response to laminar fluid shear stress : IEP:RGD response to lipopolysaccharide : IEP:RGD response to nutrient levels : IEP:RGD response to reactive oxygen species : IEP:RGD response to starvation : IEP:RGD response to transforming growth factor beta : IEP:RGD tissue regeneration : IEP:RGD

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}