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P20908

Collagen alpha-1(V) chain (P20908)

Uniprot ID P20908
Protein Name Collagen alpha-1(V) chain
Gene Name COL5A1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.054
Function Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.
GO - Molecular function
  • extracellular matrix structural constituent : IEA:Ensembl
  • heparin binding : IDA:UniProtKB
  • integrin binding : NAS:UniProtKB
  • metal ion binding : IEA:UniProtKB-KW
  • platelet-derived growth factor binding : IDA:MGI
  • proteoglycan binding : IPI:UniProtKB
GO - Biological process
  • blood vessel development : IEA:Ensembl
  • cell adhesion : IMP:UniProtKB
  • cell migration : IMP:UniProtKB
  • collagen biosynthetic process : IMP:UniProtKB
  • collagen fibril organization : IMP:UniProtKB
  • extracellular matrix organization : TAS:Reactome
  • eye morphogenesis : IMP:UniProtKB
  • heart morphogenesis : IEA:Ensembl
  • integrin biosynthetic process : IMP:UniProtKB
  • negative regulation of endodermal cell differentiation : IDA:UniProtKB
  • regulation of cellular component organization : IEA:Ensembl
  • skin development : IMP:UniProtKB
  • supramolecular fiber organization : IMP:UniProtKB
  • tendon development : IEA:Ensembl
  • wound healing, spreading of epidermal cells : IMP:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.