Tissue factor (P20352)

Uniprot ID P20352
Protein Name Tissue factor
Gene Name F3
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.0
Function Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
GO - Molecular function
  • cytokine receptor activity : IBA:GO_Central
  • phospholipid binding : ISO:MGI
  • protease binding : ISO:MGI
GO - Biological process
  • activation of cysteine-type endopeptidase activity involved in apoptotic process : ISO:MGI
  • activation of plasma proteins involved in acute inflammatory response : ISO:MGI
  • blood coagulation : ISO:MGI
  • cytokine-mediated signaling pathway : IBA:GO_Central
  • positive regulation of angiogenesis : ISO:MGI
  • positive regulation of endothelial cell proliferation : ISO:MGI
  • positive regulation of platelet-derived growth factor receptor signaling pathway : ISO:MGI
  • positive regulation of protein kinase B signaling : ISO:MGI
  • positive regulation of smooth muscle cell migration : ISO:MGI
  • protein processing : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.