Vimentin (P20152)

Uniprot ID P20152
Protein Name Vimentin
Gene Name Vim
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.742
Function Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. .
GO - Molecular function
  • double-stranded RNA binding : ISO:MGI
  • identical protein binding : ISO:MGI
  • keratin filament binding : ISO:MGI
  • kinase binding : ISO:MGI
  • protein C-terminus binding : ISO:MGI
  • protein domain specific binding : ISO:MGI
  • protein kinase binding : ISO:MGI
  • protein phosphatase 2A binding : ISO:MGI
  • scaffold protein binding : ISO:MGI
  • structural constituent of cytoskeleton : ISO:MGI
  • structural constituent of eye lens : IDA:MGI
  • structural molecule activity : IMP:MGI
GO - Biological process
  • astrocyte development : IGI:MGI
  • Bergmann glial cell differentiation : IMP:MGI
  • cellular response to interferon-gamma : IDA:MGI
  • intermediate filament organization : IGI:MGI
  • intermediate filament-based process : IMP:MGI
  • lens fiber cell development : IDA:MGI
  • negative regulation of neuron projection development : IGI:MGI
  • positive regulation of collagen biosynthetic process : ISO:MGI
  • positive regulation of gene expression : IMP:UniProtKB
  • positive regulation of glial cell proliferation : ISO:MGI
  • positive regulation of translation : ISO:MGI
  • regulation of axonogenesis : ISO:MGI
  • regulation of mRNA stability : ISO:MGI
  • regulation of Schwann cell migration : ISO:MGI
  • SMAD protein signal transduction : IDA:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.