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P20059

Hemopexin (P20059)

Uniprot ID P20059
Protein Name Hemopexin
Gene Name Hpx
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (1) Interactions
Signal peptide(a) Y Secretome P(b)
Function Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
GO - Molecular function
  • heme transporter activity : IEA:InterPro
  • metal ion binding : IEA:UniProtKB-KW
GO - Biological process
  • cellular iron ion homeostasis : IEA:InterPro
  • heme metabolic process : ISO:RGD
  • hemoglobin metabolic process : ISO:RGD
  • positive regulation of humoral immune response mediated by circulating immunoglobulin : ISO:RGD
  • positive regulation of immunoglobulin production : ISO:RGD
  • positive regulation of interferon-gamma-mediated signaling pathway : ISO:RGD
  • positive regulation of response to interferon-gamma : ISO:RGD
  • positive regulation of tyrosine phosphorylation of STAT protein : ISO:RGD
  • regulation of protein metabolic process : ISO:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.