Endoplasmic reticulum chaperone BiP (P20029)

Uniprot ID P20029
Protein Name Endoplasmic reticulum chaperone BiP
Gene Name Hspa5
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.509
Function Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:12411443, PubMed:12475965). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (PubMed:12411443). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • ATPase activity : ISS:UniProtKB
  • cadherin binding : ISO:MGI
  • enzyme binding : ISO:MGI
  • misfolded protein binding : IDA:BHF-UCL
  • protein domain specific binding : ISO:MGI
  • ribosome binding : IDA:MGI
  • ubiquitin protein ligase binding : ISO:MGI
  • unfolded protein binding : ISO:MGI
GO - Biological process
  • cellular response to antibiotic : IEA:Ensembl
  • cellular response to calcium ion : IEA:Ensembl
  • cellular response to cAMP : IEA:Ensembl
  • cellular response to drug : IEA:Ensembl
  • cellular response to gamma radiation : IEA:Ensembl
  • cellular response to glucose starvation : ISO:MGI
  • cellular response to interleukin-4 : IDA:MGI
  • cellular response to manganese ion : IEA:Ensembl
  • cellular response to nerve growth factor stimulus : IEA:Ensembl
  • cerebellar Purkinje cell layer development : IMP:BHF-UCL
  • cerebellum structural organization : IMP:BHF-UCL
  • ER overload response : IDA:MGI
  • maintenance of protein localization in endoplasmic reticulum : ISS:UniProtKB
  • negative regulation of apoptotic process : ISO:MGI
  • negative regulation of IRE1-mediated unfolded protein response : ISS:UniProtKB
  • negative regulation of protein homodimerization activity : ISS:UniProtKB
  • negative regulation of transforming growth factor beta receptor signaling pathway : IGI:MGI
  • neuron apoptotic process : IEA:Ensembl
  • neuron differentiation : IEA:Ensembl
  • positive regulation of cell migration : ISS:UniProtKB
  • positive regulation of embryonic development : TAS:BHF-UCL
  • positive regulation of neuron projection development : ISO:MGI
  • positive regulation of protein ubiquitination : IMP:BHF-UCL
  • proteolysis involved in cellular protein catabolic process : IDA:BHF-UCL
  • response to cocaine : IEA:Ensembl
  • response to endoplasmic reticulum stress : ISO:MGI
  • response to methamphetamine hydrochloride : IEA:Ensembl
  • stress response to metal ion : IEA:Ensembl
  • toxin transport : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.