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P19876

C-X-C motif chemokine 3 (P19876)

Uniprot ID P19876
Protein Name C-X-C motif chemokine 3
Gene Name CXCL3
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.746
Function Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. .
GO - Molecular function
  • chemokine activity : ISS:UniProtKB
GO - Biological process
  • antimicrobial humoral immune response mediated by antimicrobial peptide : IDA:UniProtKB
  • cellular response to lipopolysaccharide : IBA:GO_Central
  • chemokine-mediated signaling pathway : IBA:GO_Central
  • G protein-coupled receptor signaling pathway : TAS:Reactome
  • immune response : IBA:GO_Central
  • inflammatory response : IBA:GO_Central
  • killing of cells of other organism : IDA:UniProtKB
  • leukocyte chemotaxis : IBA:GO_Central
  • neutrophil chemotaxis : ISS:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.