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P19875

C-X-C motif chemokine 2 (P19875)

Uniprot ID P19875
Protein Name C-X-C motif chemokine 2
Gene Name CXCL2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.565
Function Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. .
GO - Molecular function
  • chemokine activity : IBA:GO_Central
GO - Biological process
  • antimicrobial humoral immune response mediated by antimicrobial peptide : IDA:UniProtKB
  • cellular response to lipopolysaccharide : IBA:GO_Central
  • chemokine-mediated signaling pathway : IBA:GO_Central
  • chemotaxis : TAS:ProtInc
  • cytokine-mediated signaling pathway : TAS:Reactome
  • G protein-coupled receptor signaling pathway : TAS:Reactome
  • immune response : IBA:GO_Central
  • inflammatory response : IBA:GO_Central
  • killing of cells of other organism : IDA:UniProtKB
  • leukocyte chemotaxis : IBA:GO_Central
  • neutrophil chemotaxis : IBA:GO_Central
  • response to molecule of bacterial origin : IDA:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.