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P19823

Inter-alpha-trypsin inhibitor heavy chain H2 (P19823)

Uniprot ID P19823
Protein Name Inter-alpha-trypsin inhibitor heavy chain H2
Gene Name ITIH2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.476
Function May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
GO - Molecular function
  • endopeptidase inhibitor activity : TAS:ProtInc
  • serine-type endopeptidase inhibitor activity : IEA:UniProtKB-KW
GO - Biological process
  • cellular protein metabolic process : TAS:Reactome
  • hyaluronan metabolic process : IEA:InterPro
  • post-translational protein modification : TAS:Reactome
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.