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P19801

Amiloride-sensitive amine oxidase [copper-containing] (P19801)

Uniprot ID P19801
Protein Name Amiloride-sensitive amine oxidase [copper-containing]
Gene Name AOC1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.704
Function Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.
GO - Molecular function
  • calcium ion binding : IDA:UniProtKB
  • copper ion binding : IDA:UniProtKB
  • diamine oxidase activity : IDA:UniProtKB
  • drug binding : IDA:UniProtKB
  • heparin binding : IDA:UniProtKB
  • histamine oxidase activity : IEA:UniProtKB-EC
  • methylputrescine oxidase activity : IEA:UniProtKB-EC
  • primary amine oxidase activity : IDA:UniProtKB
  • propane-1,3-diamine oxidase activity : IEA:UniProtKB-EC
  • protein homodimerization activity : IPI:UniProtKB
  • protein-containing complex binding : IDA:UniProtKB
  • quinone binding : IDA:UniProtKB
  • zinc ion binding : IDA:UniProtKB
GO - Biological process
  • amine metabolic process : IBA:GO_Central
  • cellular response to azide : IDA:UniProtKB
  • cellular response to copper ion : IDA:UniProtKB
  • cellular response to copper ion starvation : IDA:UniProtKB
  • cellular response to heparin : TAS:UniProtKB
  • cellular response to histamine : IDA:UniProtKB
  • neutrophil degranulation : TAS:Reactome
  • oxidation-reduction process : IDA:UniProtKB
  • response to antibiotic : IDA:UniProtKB
  • response to drug : IDA:UniProtKB
  • xenobiotic metabolic process : TAS:Reactome
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.