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P19637

Tissue-type plasminogen activator (P19637)

Uniprot ID P19637
Protein Name Tissue-type plasminogen activator
Gene Name Plat
Species Rattus norvegicus (Rat)
Basic Information Experiments (2) Disease (27) Interactions
Signal peptide(a) Y Secretome P(b) 0.645
Function Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events.
GO - Molecular function
  • phosphoprotein binding : ISO:RGD
  • serine-type endopeptidase activity : ISO:RGD
  • signaling receptor binding : ISO:RGD
GO - Biological process
  • cellular response to dexamethasone stimulus : IEP:RGD
  • cellular response to follicle-stimulating hormone stimulus : IEP:RGD
  • cellular response to luteinizing hormone stimulus : IEP:RGD
  • negative regulation of proteolysis : ISO:RGD
  • plasminogen activation : IDA:RGD
  • platelet-derived growth factor receptor signaling pathway : ISO:RGD
  • positive regulation of ovulation : IMP:RGD
  • proteolysis : ISO:RGD
  • regulation of synaptic plasticity : IEP:RGD
  • response to cAMP : IEP:RGD
  • response to fatty acid : IEP:RGD
  • response to hypoxia : ISO:RGD
  • smooth muscle cell migration : ISO:RGD
  • synaptic transmission, glutamatergic : IMP:RGD
  • trans-synaptic signaling by BDNF, modulating synaptic transmission : ISO:RGD
  • wound healing : IEP:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.