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P19468

Glutamate--cysteine ligase catalytic subunit (P19468)

Uniprot ID P19468
Protein Name Glutamate--cysteine ligase catalytic subunit
Gene Name Gclc
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function
GO - Molecular function
  • ADP binding : ISS:UniProtKB
  • ATP binding : IEA:UniProtKB-KW
  • coenzyme binding : ISS:UniProtKB
  • glutamate binding : ISS:UniProtKB
  • glutamate-cysteine ligase activity : IDA:RGD
  • magnesium ion binding : ISS:UniProtKB
  • protein heterodimerization activity : ISO:RGD
  • protein-containing complex binding : IDA:RGD
GO - Biological process
  • aging : IEP:RGD
  • cell redox homeostasis : ISS:UniProtKB
  • cellular response to fibroblast growth factor stimulus : IEP:RGD
  • cellular response to follicle-stimulating hormone stimulus : IEP:RGD
  • cellular response to glucose stimulus : IEP:RGD
  • cellular response to hepatocyte growth factor stimulus : IEP:RGD
  • cellular response to insulin stimulus : IEP:RGD
  • cellular response to mechanical stimulus : IEP:RGD
  • cellular response to thyroxine stimulus : IEP:RGD
  • cysteine metabolic process : ISS:UniProtKB
  • glutamate metabolic process : ISS:UniProtKB
  • glutathione biosynthetic process : IMP:RGD
  • glutathione metabolic process : ISO:RGD
  • L-ascorbic acid metabolic process : ISO:RGD
  • negative regulation of apoptotic process : ISS:UniProtKB
  • negative regulation of extrinsic apoptotic signaling pathway : ISO:RGD
  • negative regulation of hepatic stellate cell activation : IMP:RGD
  • negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway : ISO:RGD
  • negative regulation of neuron apoptotic process : IMP:RGD
  • negative regulation of protein ubiquitination : ISO:RGD
  • negative regulation of transcription, DNA-templated : ISS:UniProtKB
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process : ISO:RGD
  • regulation of blood vessel diameter : ISS:UniProtKB
  • regulation of mitochondrial depolarization : ISO:RGD
  • response to activity : IEP:RGD
  • response to arsenic-containing substance : ISO:RGD
  • response to cadmium ion : IEP:RGD
  • response to heat : ISS:UniProtKB
  • response to hormone : ISS:UniProtKB
  • response to human chorionic gonadotropin : IEP:RGD
  • response to interleukin-1 : IEP:RGD
  • response to nitrosative stress : IMP:RGD
  • response to nutrient : IEP:RGD
  • response to oxidative stress : IMP:RGD
  • response to xenobiotic stimulus : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.