| Signal peptide(a) |
N |
Secretome P(b) |
0.573 |
| Function |
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. |
| GO - Molecular function |
- cell adhesion molecule binding : IDA:BHF-UCL
- integrin binding : IDA:BHF-UCL
- primary amine oxidase activity : IDA:UniProtKB
|
| GO - Biological process |
- amine metabolic process : IDA:UniProtKB
- B cell differentiation : IC:BHF-UCL
- calcium-mediated signaling using intracellular calcium source : IGI:UniProtKB
- cell adhesion : IDA:BHF-UCL
- cell-cell adhesion in response to extracellular stimulus : IGI:ARUK-UCL
- cell-matrix adhesion : IDA:UniProtKB
- cellular response to amyloid-beta : IGI:ARUK-UCL
- cytokine-mediated signaling pathway : TAS:Reactome
- extracellular matrix organization : TAS:Reactome
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules : IDA:BHF-UCL
- heterotypic cell-cell adhesion : IGI:ARUK-UCL
- interferon-gamma-mediated signaling pathway : TAS:Reactome
- leukocyte cell-cell adhesion : IDA:BHF-UCL
- leukocyte tethering or rolling : IDA:UniProtKB
- membrane to membrane docking : IEP:BHF-UCL
- positive regulation of T cell proliferation : IDA:BHF-UCL
- regulation of immune response : TAS:Reactome
|