| Signal peptide(a) |
N |
Secretome P(b) |
0.646 |
| Function |
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Can metabolize 1-chloro-2,4-dinitrobenzene. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity). . |
| GO - Molecular function |
- dinitrosyl-iron complex binding : ISO:MGI
- drug binding : ISS:BHF-UCL
- glutathione binding : ISO:MGI
- glutathione peroxidase activity : ISO:MGI
- glutathione transferase activity : IDA:MGI
- JUN kinase binding : IPI:BHF-UCL
- kinase regulator activity : IMP:BHF-UCL
- protein kinase binding : ISO:MGI
- S-nitrosoglutathione binding : ISO:MGI
|
| GO - Biological process |
- animal organ regeneration : ISS:BHF-UCL
- cellular response to cell-matrix adhesion : ISS:BHF-UCL
- cellular response to epidermal growth factor stimulus : ISS:BHF-UCL
- cellular response to glucocorticoid stimulus : ISS:BHF-UCL
- cellular response to insulin stimulus : ISS:BHF-UCL
- cellular response to lipopolysaccharide : IDA:BHF-UCL
- common myeloid progenitor cell proliferation : IMP:BHF-UCL
- glutathione metabolic process : IDA:MGI
- negative regulation of acute inflammatory response : NAS:BHF-UCL
- negative regulation of apoptotic process : TAS:BHF-UCL
- negative regulation of ERK1 and ERK2 cascade : IDA:BHF-UCL
- negative regulation of extrinsic apoptotic signaling pathway : ISS:BHF-UCL
- negative regulation of fibroblast proliferation : IMP:BHF-UCL
- negative regulation of I-kappaB kinase/NF-kappaB signaling : IDA:BHF-UCL
- negative regulation of interleukin-1 beta production : IDA:BHF-UCL
- negative regulation of JUN kinase activity : IDA:BHF-UCL
- negative regulation of leukocyte proliferation : IMP:BHF-UCL
- negative regulation of MAP kinase activity : ISS:BHF-UCL
- negative regulation of monocyte chemotactic protein-1 production : IDA:BHF-UCL
- negative regulation of neutrophil aggregation : NAS:BHF-UCL
- negative regulation of nitric-oxide synthase biosynthetic process : IDA:BHF-UCL
- negative regulation of peroxidase activity : IDA:BHF-UCL
- negative regulation of stress-activated MAPK cascade : IDA:BHF-UCL
- negative regulation of tumor necrosis factor production : IDA:BHF-UCL
- oligodendrocyte development : ISS:BHF-UCL
- positive regulation of superoxide anion generation : IMP:BHF-UCL
- regulation of ERK1 and ERK2 cascade : IDA:BHF-UCL
- regulation of stress-activated MAPK cascade : IDA:BHF-UCL
- response to amino acid : ISS:BHF-UCL
- response to estradiol : ISS:BHF-UCL
- response to ethanol : ISS:BHF-UCL
- response to L-ascorbic acid : ISS:BHF-UCL
- response to nutrient levels : ISS:BHF-UCL
- response to reactive oxygen species : IDA:BHF-UCL
- response to toxic substance : ISS:BHF-UCL
- xenobiotic metabolic process : ISS:UniProtKB
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