Fatty acid synthase (P19096)

Uniprot ID P19096
Protein Name Fatty acid synthase
Gene Name Fasn
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.509
Function Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.
GO - Molecular function
  • 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity : IEA:UniProtKB-EC
  • 3-oxo-glutaryl-[acp] methyl ester reductase activity : IEA:UniProtKB-EC
  • 3-oxo-pimeloyl-[acp] methyl ester reductase activity : IEA:UniProtKB-EC
  • 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity : IEA:UniProtKB-EC
  • 3-oxoacyl-[acyl-carrier-protein] synthase activity : IEA:UniProtKB-EC
  • [acyl-carrier-protein] S-acetyltransferase activity : IEA:UniProtKB-EC
  • [acyl-carrier-protein] S-malonyltransferase activity : IEA:UniProtKB-EC
  • cadherin binding : ISO:MGI
  • drug binding : ISO:MGI
  • enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity : IEA:UniProtKB-EC
  • fatty acid synthase activity : IDA:MGI
  • identical protein binding : ISO:MGI
  • myristoyl-[acyl-carrier-protein] hydrolase activity : IEA:UniProtKB-EC
  • NADPH binding : ISO:MGI
  • oleoyl-[acyl-carrier-protein] hydrolase activity : IEA:UniProtKB-EC
  • palmitoyl-[acyl-carrier-protein] hydrolase activity : IEA:UniProtKB-EC
  • phosphopantetheine binding : IEA:InterPro
  • protein homodimerization activity : ISO:MGI
GO - Biological process
  • acetyl-CoA metabolic process : ISO:MGI
  • cellular response to interleukin-4 : IDA:MGI
  • fatty acid biosynthetic process : IDA:MGI
  • mammary gland development : IMP:CACAO
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.