| Signal peptide(a) |
N |
Secretome P(b) |
0.109 |
| Function |
Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. . |
| GO - Molecular function |
- alpha-catenin binding : IPI:BHF-UCL
- beta-catenin binding : IPI:UniProtKB
- cadherin binding : IBA:GO_Central
- calcium ion binding : ISS:UniProtKB
- cytoskeletal protein binding : IBA:GO_Central
- gamma-catenin binding : IPI:BHF-UCL
- identical protein binding : IEA:Ensembl
- protein kinase binding : IEA:Ensembl
- protein phosphatase binding : IEA:Ensembl
|
| GO - Biological process |
- adherens junction organization : IBA:GO_Central
- blood vessel morphogenesis : IBA:GO_Central
- brain development : IBA:GO_Central
- brain morphogenesis : IEA:Ensembl
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules : IBA:GO_Central
- cell adhesion : TAS:ProtInc
- cell migration : IEA:Ensembl
- cell morphogenesis : IBA:GO_Central
- cell-cell adhesion : ISS:UniProtKB
- cell-cell adhesion mediated by cadherin : ISS:UniProtKB
- cell-cell junction assembly : IBA:GO_Central
- cellular protein metabolic process : TAS:Reactome
- cerebral cortex development : IEA:Ensembl
- glial cell differentiation : ISS:UniProtKB
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules : IEA:Ensembl
- homeostasis of number of cells : IEA:Ensembl
- homophilic cell adhesion via plasma membrane adhesion molecules : IBA:GO_Central
- multicellular organism development : IBA:GO_Central
- negative regulation of canonical Wnt signaling pathway : IEA:Ensembl
- neuroepithelial cell differentiation : IEA:Ensembl
- neuroligin clustering involved in postsynaptic membrane assembly : IEA:Ensembl
- neuronal stem cell population maintenance : ISS:UniProtKB
- positive regulation of MAPK cascade : IEA:Ensembl
- positive regulation of muscle cell differentiation : TAS:Reactome
- positive regulation of synaptic vesicle clustering : IEA:Ensembl
- post-translational protein modification : TAS:Reactome
- protein localization to plasma membrane : IEA:Ensembl
- radial glial cell differentiation : IEA:Ensembl
- regulation of axonogenesis : IBA:GO_Central
- regulation of oligodendrocyte progenitor proliferation : IEA:Ensembl
- regulation of postsynaptic density protein 95 clustering : IEA:Ensembl
- regulation of synaptic transmission, glutamatergic : IBA:GO_Central
- striated muscle cell differentiation : IEA:Ensembl
- synapse assembly : IBA:GO_Central
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