Syndecan-1 (P18827)

Uniprot ID P18827
Protein Name Syndecan-1
Gene Name SDC1
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b) 0.456
Function Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). .
GO - Molecular function
  • identical protein binding : IPI:IntAct
  • protein C-terminus binding : IPI:UniProtKB
GO - Biological process
  • canonical Wnt signaling pathway : IEA:Ensembl
  • cell migration : IBA:GO_Central
  • cytokine-mediated signaling pathway : TAS:Reactome
  • glycosaminoglycan biosynthetic process : TAS:Reactome
  • glycosaminoglycan catabolic process : TAS:Reactome
  • inflammatory response : IEA:Ensembl
  • leukocyte migration : TAS:Reactome
  • myoblast development : ISS:UniProtKB
  • odontogenesis : IEA:Ensembl
  • positive regulation of exosomal secretion : IMP:UniProtKB
  • positive regulation of extracellular exosome assembly : IMP:UniProtKB
  • response to calcium ion : IEA:Ensembl
  • response to cAMP : IEA:Ensembl
  • response to glucocorticoid : IEA:Ensembl
  • response to hydrogen peroxide : IEA:Ensembl
  • retinoid metabolic process : TAS:Reactome
  • Sertoli cell development : IEA:Ensembl
  • striated muscle cell development : IEP:UniProtKB
  • ureteric bud development : IEA:Ensembl
  • wound healing : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.