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P18437

Non-histone chromosomal protein HMG-17 (P18437)

Uniprot ID P18437
Protein Name Non-histone chromosomal protein HMG-17
Gene Name Hmgn2
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). .
GO - Molecular function
  • nucleosomal DNA binding : IEA:InterPro
GO - Biological process
  • antimicrobial humoral immune response mediated by antimicrobial peptide : ISO:RGD
  • killing of cells of other organism : ISO:RGD
  • negative regulation of transcription by RNA polymerase II : ISO:RGD
  • regulation of development, heterochronic : ISO:RGD
  • regulation of transcription by RNA polymerase II : ISO:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.