| Signal peptide(a) |
Y |
Secretome P(b) |
|
| Function |
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. . |
| GO - Molecular function |
- androgen receptor binding : ISO:RGD
- calcium ion binding : IDA:RGD
- carbohydrate binding : ISO:RGD
- hormone binding : IPI:RGD
- integrin binding : ISO:RGD
- iron ion binding : IDA:RGD
- mRNA binding : IDA:BHF-UCL
- peptide binding : IDA:RGD
- ubiquitin protein ligase binding : ISO:RGD
- unfolded protein binding : IEA:InterPro
|
| GO - Biological process |
- cardiac muscle cell differentiation : IEP:RGD
- cellular response to lithium ion : IEP:RGD
- cellular response to organic substance : IEP:RGD
- cellular senescence : ISO:RGD
- cortical actin cytoskeleton organization : ISO:RGD
- endoplasmic reticulum unfolded protein response : IBA:GO_Central
- negative regulation of cell cycle arrest : ISO:RGD
- negative regulation of intracellular steroid hormone receptor signaling pathway : ISO:RGD
- negative regulation of neuron differentiation : ISO:RGD
- negative regulation of retinoic acid receptor signaling pathway : ISO:RGD
- negative regulation of transcription by RNA polymerase II : ISO:RGD
- negative regulation of transcription, DNA-templated : ISO:RGD
- negative regulation of translation : ISO:RGD
- negative regulation of trophoblast cell migration : ISO:RGD
- peptide antigen assembly with MHC class I protein complex : ISO:RGD
- positive regulation of cell cycle : ISO:RGD
- positive regulation of cell population proliferation : ISO:RGD
- positive regulation of dendritic cell chemotaxis : ISO:RGD
- positive regulation of endothelial cell migration : ISO:RGD
- positive regulation of gene expression : ISO:RGD
- positive regulation of NIK/NF-kappaB signaling : ISO:RGD
- positive regulation of phagocytosis : ISO:RGD
- positive regulation of substrate adhesion-dependent cell spreading : ISO:RGD
- protein export from nucleus : ISO:RGD
- protein folding : IBA:GO_Central
- protein localization to nucleus : ISO:RGD
- protein stabilization : ISS:UniProtKB
- regulation of meiotic nuclear division : ISO:RGD
- response to drug : IEP:RGD
- response to estradiol : IEP:RGD
- response to organic substance : IEP:RGD
- response to testosterone : IEP:RGD
- spermatogenesis : IEP:RGD
|