Peptidyl-prolyl cis-trans isomerase A (P18303)

Uniprot ID P18303
Protein Name Peptidyl-prolyl cis-trans isomerase A
Gene Name Ppia
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. .
GO - Molecular function
  • cyclosporin A binding : IDA:RGD
  • peptidyl-prolyl cis-trans isomerase activity : ISS:UniProtKB
  • unfolded protein binding : IBA:GO_Central
GO - Biological process
  • lipid droplet organization : ISO:RGD
  • negative regulation of phosphoprotein phosphatase activity : IDA:RGD
  • neuron differentiation : ISO:RGD
  • positive regulation of protein secretion : ISO:RGD
  • positive regulation of viral genome replication : ISO:RGD
  • protein peptidyl-prolyl isomerization : ISS:UniProtKB
  • protein refolding : IBA:GO_Central
  • regulation of viral genome replication : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.