Cathepsin D (P18242)

Uniprot ID P18242
Protein Name Cathepsin D
Gene Name Ctsd
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.726
Function Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. .
GO - Molecular function
  • aspartic-type endopeptidase activity : IDA:MGI
  • endopeptidase activity : ISO:MGI
  • hydrolase activity : IDA:MGI
  • peptidase activity : IDA:MGI
  • peptide binding : ISO:MGI
GO - Biological process
  • autophagosome assembly : IMP:MGI
  • protein catabolic process : IBA:GO_Central
  • proteolysis : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.