Vinculin (P18206)

Uniprot ID P18206
Protein Name Vinculin
Gene Name VCL
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.309
Function Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. .
GO - Molecular function
  • actin binding : IDA:BHF-UCL
  • alpha-catenin binding : IPI:UniProtKB
  • beta-catenin binding : ISS:BHF-UCL
  • cadherin binding : HDA:BHF-UCL
  • dystroglycan binding : IPI:UniProtKB
  • structural molecule activity : IEA:InterPro
  • ubiquitin protein ligase binding : IPI:ParkinsonsUK-UCL
GO - Biological process
  • adherens junction assembly : IMP:BHF-UCL
  • apical junction assembly : IMP:UniProtKB
  • axon extension : IEA:Ensembl
  • cell adhesion : TAS:UniProtKB
  • cell-matrix adhesion : TAS:BHF-UCL
  • epithelial cell-cell adhesion : IMP:BHF-UCL
  • lamellipodium assembly : ISS:UniProtKB
  • morphogenesis of an epithelium : IMP:BHF-UCL
  • muscle contraction : TAS:Reactome
  • negative regulation of cell migration : TAS:UniProtKB
  • neutrophil degranulation : TAS:Reactome
  • platelet aggregation : HMP:UniProtKB
  • platelet degranulation : TAS:Reactome
  • protein localization to cell surface : IMP:BHF-UCL
  • regulation of establishment of endothelial barrier : IDA:ARUK-UCL
  • regulation of focal adhesion assembly : IMP:ARUK-UCL
  • regulation of protein localization to adherens junction : IMP:ARUK-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.