Signal peptide(a) |
N |
Secretome P(b) |
0.309 |
Function |
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. . |
GO - Molecular function |
- actin binding : IDA:BHF-UCL
- alpha-catenin binding : IPI:UniProtKB
- beta-catenin binding : ISS:BHF-UCL
- cadherin binding : HDA:BHF-UCL
- dystroglycan binding : IPI:UniProtKB
- structural molecule activity : IEA:InterPro
- ubiquitin protein ligase binding : IPI:ParkinsonsUK-UCL
|
GO - Biological process |
- adherens junction assembly : IMP:BHF-UCL
- apical junction assembly : IMP:UniProtKB
- axon extension : IEA:Ensembl
- cell adhesion : TAS:UniProtKB
- cell-matrix adhesion : TAS:BHF-UCL
- epithelial cell-cell adhesion : IMP:BHF-UCL
- lamellipodium assembly : ISS:UniProtKB
- morphogenesis of an epithelium : IMP:BHF-UCL
- muscle contraction : TAS:Reactome
- negative regulation of cell migration : TAS:UniProtKB
- neutrophil degranulation : TAS:Reactome
- platelet aggregation : HMP:UniProtKB
- platelet degranulation : TAS:Reactome
- protein localization to cell surface : IMP:BHF-UCL
- regulation of establishment of endothelial barrier : IDA:ARUK-UCL
- regulation of focal adhesion assembly : IMP:ARUK-UCL
- regulation of protein localization to adherens junction : IMP:ARUK-UCL
|