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P18077

60S ribosomal protein L35a (P18077)

Uniprot ID P18077
Protein Name 60S ribosomal protein L35a
Gene Name RPL35A
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.852
Function Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site. .
GO - Molecular function
  • RNA binding : HDA:UniProtKB
  • structural constituent of ribosome : IBA:GO_Central
  • tRNA binding : IEA:UniProtKB-KW
GO - Biological process
  • cytoplasmic translation : IBA:GO_Central
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay : TAS:Reactome
  • ribosomal large subunit biogenesis : IMP:UniProtKB
  • rRNA processing : IMP:UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane : TAS:Reactome
  • translation : NAS:UniProtKB
  • translational initiation : TAS:Reactome
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.